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Oxford University Press (OUP), Bioinformatics, 15(25), p. 1862-1868

DOI: 10.1093/bioinformatics/btp334

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CORAL: aligning conserved core regions across domain families

Journal article published in 2009 by Jessica H. Fong, Aron Marchler-Bauer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: Homologous protein families share highly conserved sequence and structure regions that are frequent targets for comparative analysis of related proteins and families. Many protein families, such as the curated domain families in the Conserved Domain Database (CDD), exhibit similar structural cores. To improve accuracy in aligning such protein families, we propose a profile–profile method CORAL that aligns individual core regions as gap-free units.