Published in
Nature Research, Scientific Reports, 1(9), 2019
DOI: 10.1038/s41598-019-38752-y
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Structural basis for chemically-induced homodimerization of a single domain antibody
Journal article published in 2019 by
Jean Lesne,
Hung-Ju Chang,
Angelique De Visch,
Matteo Paloni,
Philippe Barthe 
,
Jean-François Guichou,
Pauline Mayonove,
Alessandro Barducci,
Gilles Labesse,
Jerome Bonnet,
Martin Cohen-Gonsaud
,
Jean-François Guichou,
Pauline Mayonove,
Alessandro Barducci,
Gilles Labesse,
Jerome Bonnet,
Martin Cohen-Gonsaud
This paper is made freely available by the publisher.
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Abstract
AbstractChemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic gene networks. Here we provide the structural basis for caffeine-induced homo-dimerization of acVHH.