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Taylor and Francis Group, Laterality, 2(18), p. 251-261, 2013

DOI: 10.1080/1357650x.2012.660164

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Non-replication of an association of Apolipoprotein E2 with sinistrality

Journal article published in 2013 by Brian J. Piper, Alia L. Yasen, Amy E. Taylor, Jonatan R. Ruiz, J. William Gaynor, Catherine A. Dayger, Marcela Gonzalez-Gross ORCID, Oh D. Kwon ORCID, Lars-Göran Nilsson, Ian N. M. Day, Jacob Raber, Jeremy K. Miller
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Abstract

A recent report found that left-handed adolescents were more than three times more likely to have an Apolipoprotein (APOE) ϵ2 allele. This study was unable to replicate this association in young adults (N=166). A meta-analysis of nine other datasets (N=360 to 7559, Power > 0.999) including that of National Alzheimer's Coordinating Center also failed to find an over-representation of ϵ2 among left-handers indicating that this earlier outcome was most likely a statistical artefact.