Published in
American Association for the Advancement of Science, Science Advances, 3(6), 2020
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Structure-guided discovery of a single-domain antibody agonist against human apelin receptor
Journal article published in 2020 by
Yanbin Ma 
,
Yao Ding,
Xianqiang Song,
Xiaochuan Ma,
Xun Li ,
Ning Zhang,
Yunpeng Song,
Yaping Sun ,
Yuqing Shen,
Wenge Zhong,
Liaoyuan A. Hu ,
Yingli Ma ,
Mei-Yun Zhang
,
Yao Ding,
Xianqiang Song,
Xiaochuan Ma,
Xun Li ,
Ning Zhang,
Yunpeng Song,
Yaping Sun ,
Yuqing Shen,
Wenge Zhong,
Liaoyuan A. Hu ,
Yingli Ma ,
Mei-Yun Zhang
This paper is made freely available by the publisher.
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Abstract
We converted a potent antagonistic sdAb JN241 to an agonistic sdAb JN241-9 to human APJ by structure-guided rational design.