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BioMed Central, Respiratory Research, 1(15), 2014

DOI: 10.1186/1465-9921-15-47

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Inflammatory cytokines in pulmonary hypertension

Journal article published in 2014 by Alexandra Groth, Bart Vrugt, Matthias Brock ORCID, Rudolf Speich, Silvia Ulrich, Lars C. Huber
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Pulmonary hypertension is an “umbrella term” used for a spectrum of entities resulting in an elevation of the pulmonary arterial pressure. Clinical symptoms include dyspnea and fatigue which in the absence of adequate therapeutic intervention may lead to progressive right heart failure and death. The pathogenesis of pulmonary hypertension is characterized by three major processes including vasoconstriction, vascular remodeling and microthrombotic events. In addition accumulating evidence point to a cytokine driven inflammatory process as a major contributor to the development of pulmonary hypertension. This review summarizes the latest clinical and experimental developments in inflammation associated with pulmonary hypertension with special focus on Interleukin-6, and its role in vascular remodeling in pulmonary hypertension.