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Objective: To know the barriers in the process of building family cultural care for the child in the hospital. Methodology: This is a qualitative study with a cross-cultural theoretical reference of Madeleine Leininger, called Theory of Diversity and Cultural Universality of Care, and with a methodological reference of the ethno-inference. It was developed in 2017 at the pediatric unit of a university hospital in the south of Brazil, through non-participant observation, participant observation and interview with 15 family caregivers of hospitalized children. The data was coded, classified and scrutinized to identify the saturation of ideas and similar or different patterns; also, it was re-coded and the theoretical formulations and recommendations were performed. Ethical aspects were followed, according to the Resolution of the National Research Ethics Council 466/2012. Results: The data showed as a barrier the need for hospitalization as a factor of family vulnerability, control of the unit’s health team members, hospital norms and routines, and the need to transgress as a manifestation of family care. Conclusion: Cultural care is a process that aggregates knowledge and can be considered a new paradigm for the accomplishment of nursing care by providing the mutual growth and construction of new knowledge, an affective, reflexive, human and empathic relationship between the nurse, the child and the family.