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Oxford University Press (OUP), Carcinogenesis: Integrative Cancer Research, 2(35), p. 356-364

DOI: 10.1093/carcin/bgt391

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Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer

Journal article published in 2013 by Zongli Xu ORCID, Jack A. Taylor
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Using a large cohort study, we identify 749 CpG sites having consistent age-related methylation changes in blood and other normal tissues. Increasingly methylated aging sites are significantly overmethylated in many human cancers, perhaps explaining in part increased cancer risk with age.