Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2(63), 2019
DOI: 10.1128/aac.01393-18
Links
Tools
Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda
Journal article published in 2018 by
Erika Wallender 
,
Nan Zhang,
Melissa Conrad,
Abel Kakuru ,
Mary Muhindo,
Patrick Tumwebaze,
Richard Kajubi,
Daniel Mota,
Diane Havlir,
Jennifer Legac,
Moses Kamya,
Grant Dorsey,
Prasanna Jagannathan ,
Francesca Aweeka,
Philip J. Rosenthal
and other authors.
,
Nan Zhang,
Melissa Conrad,
Abel Kakuru ,
Mary Muhindo,
Patrick Tumwebaze,
Richard Kajubi,
Daniel Mota,
Diane Havlir,
Jennifer Legac,
Moses Kamya,
Grant Dorsey,
Prasanna Jagannathan ,
Francesca Aweeka,
Philip J. Rosenthal
and other authors.
This paper is made freely available by the publisher.
Full text: Download
Data provided by 
Abstract
Dihydroartemisinin-piperaquine (DHA-PQ) is under study for intermittent preventive treatment during pregnancy (IPTp), but it may accelerate selection for drug resistance. Understanding the relationships between piperaquine concentration, prevention of parasitemia, and selection for decreased drug sensitivity can inform control policies and optimization of DHA-PQ dosing.