Published in

American Society for Microbiology, Journal of Virology, 8(76), p. 4108-4112, 2002

DOI: 10.1128/jvi.76.8.4108-4112.2002

Links

Tools

Export citation

Search in Google Scholar

Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication

Journal article published in 2002 by Todd M. Allen, Lorenzo Mortara, Bianca R. Mothé, Max Liebl, Peicheng Jing, Briana Calore, Marian Piekarczyk, Richard Ruddersdorf, David H. O'Connor ORCID, X. Wang, Chenxi Wang, David B. Allison, John D. Altman, Alessandro Sette, Ronald C. Desrosiers and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

ABSTRACT The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.