Dissemin is shutting down on January 1st, 2025

Published in

MDPI, Brain Sciences, 2(9), p. 19, 2019

DOI: 10.3390/brainsci9020019

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Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (Callithrix jacchus) Brain

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

Microelectrode implants are an important tool in neuroscience research and in developing brain–machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces chronic utility. However, studies in non-human primates are scarce, with none to date in marmosets. We used glial fibrillary acidic protein (GFAP) immunostaining to characterize the acute and chronic response of the marmoset brain to microelectrodes. By using densitometry, we showed that marmoset astrocytes surround brain implants and that a glial scar is formed over time, with significant increase in the chronic condition relative to the acute condition animal.