Published in
American Society for Microbiology, Infection and Immunity, 2(87), 2019
DOI: 10.1128/iai.00604-18
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Nontypeable Haemophilus influenzae Invasive Blood Isolates Are Mainly Phosphorylcholine Negative and Show Decreased Complement-Mediated Killing That Is Associated with Lower Binding of IgM and CRP in Comparison to Colonizing Isolates from the Oropharynx
Journal article published in 2018 by
Jeroen D. Langereis 
,
Amelieke J. H. Cremers ,
Marloes Vissers,
Josine van Beek,
Jacques F. Meis ,
Marien I. de Jonge
,
Amelieke J. H. Cremers ,
Marloes Vissers,
Josine van Beek,
Jacques F. Meis ,
Marien I. de Jonge
This paper is made freely available by the publisher.
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Abstract
Nontypeable Haemophilus influenzae (NTHi) bacteria express various molecules that contribute to their virulence. The presence of phosphocholine (PCho) on NTHi lipooligosaccharide increases adhesion to epithelial cells and is an advantage for the bacterium, enabling nasopharyngeal colonization, as measured in humans and animal models.