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Ivyspring International Publisher, International Journal of Medical Sciences, 12(10), p. 1727-1739

DOI: 10.7150/ijms.6884

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DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma

Journal article published in 2013 by Goot Heah Khor, Gabriele Ruth Anisah Froemming, Rosnah Binti Zain, Mannil Thomas Abraham, Effat Omar, Su Keng Tan, Aik Choon Tan, Vui King Vincent-Chong, Kwai Lin Thong ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis, and therapeutic treatment of oral squamous cell carcinoma (OSCC). The objectives of this study were to screen and validate differentially hypermethylated genes in OSCC and correlate the hypermethylation-induced genes with demographic, clinocopathological characteristics and survival rate of OSCC.