Shadows and normal light illumination and road and non-road areas are two pairs of contradictory symmetrical individuals. To achieve accurate road detection, it is necessary to remove interference caused by uneven illumination, such as shadows. This paper proposes a road detection algorithm based on a learning and illumination-independent image to solve the following problems: First, most road detection methods are sensitive to variation of illumination. Second, with traditional road detection methods based on illumination invariability, it is difficult to determine the calibration angle of the camera axis, and the sampling of road samples can be distorted. The proposed method contains three stages: The establishment of a classifier, the online capturing of an illumination-independent image, and the road detection. During the establishment of a classifier, a support vector machine (SVM) classifier for the road block is generated through training with the multi-feature fusion method. During the online capturing of an illumination-independent image, the road interest region is obtained by using a cascaded Hough transform parameterized by a parallel coordinate system. Five road blocks are obtained through the SVM classifier, and the RGB (Red, Green, Blue) space of the combined road blocks is converted to a geometric mean log chromatic space. Next, the camera axis calibration angle for each frame is determined according to the Shannon entropy so that the illumination-independent image of the respective frame is obtained. During the road detection, road sample points are extracted with the random sampling method. A confidence interval classifier of the road is established, which could separate a road from its background. This paper is based on public datasets and video sequences, which records roads of Chinese cities, suburbs, and schools in different traffic scenes. The author compares the method proposed in this paper with other sound video-based road detection methods and the results show that the method proposed in this paper can achieve a desired detection result with high quality and robustness. Meanwhile, the whole detection system can meet the real-time processing requirement.