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Public Library of Science, PLoS ONE, 10(8), p. e78238, 2013

DOI: 10.1371/journal.pone.0078238

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5-HTT Deficiency Affects Neuroplasticity and Increases Stress Sensitivity Resulting in Altered Spatial Learning Performance in the Morris Water Maze but Not in the Barnes Maze

Journal article published in 2013 by Margherita M. Karabeg, Sandra Grauthoff, Sina Y. Kollert, Rebecca S. Heiming, Friederike Jansen, Sandy Popp, Sylvia Kaiser, Magdalena Weidner ORCID, Klaus-Peter Lesch, Norbert Sachser, Angelika G. Schmitt, Lars Lewejohann
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The purpose of this study was to evaluate whether spatial hippocampus-dependent learning is affected by the serotonergic system and stress. Therefore, 5-HTT knockout (-/-), heterozygous (+/-) and wildtype (+/+) mice were subjected to the Barnes maze (BM) and the Morris water maze (WM), the latter being discussed as more aversive. Additionally, immediate early gene (IEG) expression, hippocampal adult neurogenesis (aN), and blood plasma corticosterone were analyzed.