Published in
American Association for the Advancement of Science, Science Translational Medicine, 510(11), 2019
DOI: 10.1126/scitranslmed.aav5055
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Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
Journal article published in 2019 by
Ioannis Akoumianakis 
,
Fabio Sanna ,
Marios Margaritis ,
Ileana Badi ,
Nadia Akawi ,
Laura Herdman ,
Patricia Coutinho ,
Harry Fagan ,
Alexios S. Antonopoulos ,
Evangelos K. Oikonomou ,
Sheena Thomas ,
Amy P. Chiu,
Surawee Chuaiphichai,
Christos P. Kotanidis ,
Constantinos Christodoulides
and other authors.
,
Fabio Sanna ,
Marios Margaritis ,
Ileana Badi ,
Nadia Akawi ,
Laura Herdman ,
Patricia Coutinho ,
Harry Fagan ,
Alexios S. Antonopoulos ,
Evangelos K. Oikonomou ,
Sheena Thomas ,
Amy P. Chiu,
Surawee Chuaiphichai,
Christos P. Kotanidis ,
Constantinos Christodoulides
and other authors.
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Abstract
Adipose-secreted WNT5A triggers vascular disease in obesity, activating vascular smooth muscle cell migration by an NADPH oxidase–dependent mechanism.