Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

Huang, Jie; Öhrvik, John; Fw, Asselbergs; Sabater-Lleal, Maria; Sy, Shin; Tregouet, David; Shin, Sy-Y.; Ding, Jingzhong; Oudot-Mellakh, Tiphaine; Nl, Smith; Smith, Nl L.; Folkersen, Lasse; Sm, Williams; Williams, Sm M.; Johnson, Ad D.; Ma, Ikram; Me, Kleber; Dm, Becker; Ikram, Mohammad A.; Jc, Mychaleckyj; Kleber, Me E.; Truong, Vinh; Jh, Moore; Tang, Weihong; Mychaleckyj, Jc C.; Yang, Qiong; Williams, Fm M. K.; Fm, Williams; Sennblad, Bengt; Moore, Jh H.; Em, Schrijvers; Dehghan, Abbas; Silbernagel, Günther; Gh, Tofler; Smith, Shelly; Tofler, Gh H.; Schrijvers, Em M. C.; Karakas, Mahir; Gj, Navis; Silveira, Angela; Navis, Gj J.; Mh, Chen; Lohman, Kurt; Jc, Hopewell; Jc, Chambers; Peters, Annette; Goel, Anuj; Hopewell, Jc C.; Strawbridge, Rj J.; Saleheen, Danish; Rj, Strawbridge; Lundmark, Per; Psaty, Bm M.; Jf, Peden; Jc, Bis; Meisinger, Christa; Peden, Jf F.; Ohrvik, J.; McKnight, Barbara; Mg, Franzosi; Taylor, Kent; Seedorf, Udo; Franzosi, Mg G.; Syvänen, Ac-C.; Collins, Rory; Yanek, Lr R.; Franco-Cereceda, Anders; Goodall, Ah H.; Lr, Yanek; van Gilst, Wh H.; Cushman, Mary; Muller-Nurasyid, M.; Wh, van Gilst; Js, Kooner; Folsom, Ar R.; Müller-Nurasyid, Martina; Matijevic, Nena; Van Gilst, W. H.; Jb, Meigs; Kooner, Js S.; Hofman, Albert; Danesh, John; Clarke, Robert; Winkelmann, Br R.; Mp, Reilly; Kathiresan, Sekar; Meigs, Jb B.; Reilly, Muredach P.; Klopp, Norman; Tb, Harris; Spector, Td D.; Harris, Tb B.; Pj, Grant; Tracy, Rp P.; Watkins, Hugh; Hl, Hillege; Grant, Pj J.; Hillege, Hl L.; Diagram, Consortium; Uitterlinden, Ag G.; Td, Spector; Lc, Becker; Consortium, CARDIoGRAM; Marz, W.; Rp, Tracy; Eriksson, Per; März, Winfried; Morange, Pe-E.; Soranzo, Nicole; Koenig, Wolfgang; van der Harst, Pim; O'Donnell, Cj J.; Pe, Morange; Hamsten, Anders; Liu, Yongmei; Cj, O'Donnell; Asselbergs, Fw W.; Baumert, Jens; Ad, Johnson; Becker, Dm M.; Chen, Mh-H.; Bm, Psaty; Chambers, Jc C.; Bo, Boehm; Am, Carter; Boehm, Bo O.; Carter, Am M.; Bis, Jc C.; Ac, Syvänen; Ah, Goodall; Ar, Folsom; Basu, Saonli; Br, Winkelmann; Becker, Lc C.; Cambien, Francois; Ag, Uitterlinden; C4d, Consortium; Cardiogenics, Consortium

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Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

Journal article published in 2012 by Jie Huang, John Öhrvik, Asselbergs Fw, Maria Sabater-Lleal, Shin Sy, David Tregouet, Sy-Y. Shin, Jingzhong Ding, Tiphaine Oudot-Mellakh, Smith Nl, Nl L. Smith, Lasse Folkersen, Williams Sm, Sm M. Williams, Ad D. Johnson and other authors.

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Abstract

We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, followed by replication analysis of genome-wide significant (P

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Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

Abstract