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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(63), 2019

DOI: 10.1128/aac.01754-18

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The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

Journal article published in 2018 by Antonela R. Palacios, María F. Mojica, Estefanía Giannini, Magdalena A. Taracila, Christopher R. Bethel, Pedro M. Alzari ORCID, Lisandro H. Otero ORCID, Sebastián Klinke ORCID, Leticia I. Llarrull, Robert A. Bonomo, Alejandro J. Vila
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Carbapenems are “last resort” β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of genes coding for carbapenemases among these bacteria is threatening these life-saving drugs.