Dissemin is shutting down on January 1st, 2025

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PAGEpress, Dermatology Reports, 2(3), p. e30, 2011

DOI: 10.4081/dr.2011.e30

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Tegafur-induced acral hyperpigmentation

Journal article published in 2011 by Vera Teixeira, Ricardo Vieira ORCID, Américo Figueiredo ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Tegafur is a prodrug of 5-fluorouracil (5-FU) with a similar spectrum of antitumor activity. It is used in the treatment of advanced gastrointestinal neoplasms. Over 5-FU, tegafur has the advantage of oral administration and less hematologic toxicity. Gastrointestinal toxicity is its main dose-limiting factor. The cutaneous adverse effects of tegafur include mucositis, photosensitivity, diffuse or nail-restricted hyperpigmentation, palmoplantar erythrodysesthesia syndrome, palmoplantar keratoderma, sclerodactyly and Raynaud phenomenon. We report here the case of a patient who developed acral hyperpigmentation during treatment with tegafur.