Elsevier, Cell Stem Cell, 5(7), p. 547-548, 2010
DOI: 10.1016/j.stem.2010.10.006
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In a recent issue of Nature Medicine, Ryan et al. (2010) uncover genetic modifiers of G-CSF responses by hematopoietic progenitors. The authors document a negative role of EGFR signaling and, provided an analogous pathway functions in humans, propose a potential new angle to promote clinical blood stem cell mobilization.