Published in
Royal Society of Chemistry, RSC Advances, 72(8), p. 41226-41236, 2018
DOI: 10.1039/c8ra07985d
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Highly functionalized pyrrolidine analogues: stereoselective synthesis and caspase-dependent apoptotic activity
Journal article published in 2018 by
Raju Suresh Kumar 
,
Abdulrahman I. Almansour,
Natarajan Arumugam ,
Faruq Mohammad ,
Waleed Shihan Alshahrani,
Kotresha D.,
Mohammad Altaf,
Mohammad Azam ,
J. Carlos Menéndez
,
Abdulrahman I. Almansour,
Natarajan Arumugam ,
Faruq Mohammad ,
Waleed Shihan Alshahrani,
Kotresha D.,
Mohammad Altaf,
Mohammad Azam ,
J. Carlos Menéndez
This paper is made freely available by the publisher.
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Abstract
Spiropyrrolidines were synthesized employing a new class of azomethine ylide for the first time and were tested for their anticancer activity, where the cell death mechanism revealed that it is occurring through the caspase-3 dependent pathway.