Bio-inspired fluorine-free and self-cleaning polymer coatings were developed using a combination of self-assembly and UV-printing processes. Nasturtium and lotus leaves were selected as natural template surfaces. A UV-curable acrylate oligomer and three acrylated siloxane comonomers with different molecular weights were used. The spontaneous migration of the comonomers towards the polymer–air interface was found to be faster for comonomers with higher molecular weight, and enabled to create hydrophobic surfaces with a water contact angle (WCA) of 105°. The replication fidelity was limited for the nasturtium surface, due to a lack of replication of the sub-micron features. It was accurate for the lotus leaf surface whose hierarchical texture, comprising micropapillae and sub-micron crystalloids, was well reproduced in the acrylate/comonomer material. The WCA of synthetic replica of lotus increased from 144° to 152° with increasing creep time under pressure to 5 min prior to polymerization. In spite of a water sliding angle above 10°, the synthetic lotus surface was self-cleaning with water droplets when contaminated with hydrophobic pepper particles, provided that the droplets had some kinetic energy.