Published in

Nature Research, Scientific Reports, 1(5), 2015

DOI: 10.1038/srep12714

Links

Tools

Export citation

Search in Google Scholar

Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress

Journal article published in 2015 by Benjamin Delatte, Jana Jeschke, Matthieu Defrance, Martin Bachman, Catherine Creppe, Emilie Calonne, Martin Bizet, Rachel Deplus, Laura Marroquí ORCID, Myriam Libin, Mirunalini Ravichandran, Françoise Mascart, Decio L. Eizirik, Adele Murrell, Tomasz P. Jurkowski and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

AbstractThe TET enzymes convert methylcytosine to the newly discovered base hydroxymethylcytosine. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains uncertain and results lackin vivomodels. Here we show a global decrease of hydroxymethylcytosine in cells treated with buthionine sulfoximine and in mice depleted for the major antioxidant enzymesGPx1 and 2. Furthermore, genome-wide profiling revealed differentially hydroxymethylated regions in coding genes and intriguingly in microRNA genes, both involved in response to oxidative stress. These results thus suggest a profound effect ofin vivooxidative stress on the global hydroxymethylome.