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Wiley, Hepatology, 2(57), p. 483-491, 2012

DOI: 10.1002/hep.25921

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Investigation of Residual Hepatitis C Virus in Presumed Recovered Subjects

Journal article published in 2012 by Kei Fujiwara, Robert D. Allison ORCID, Richard Y. Wang, Patricia Bare, Kentaro Matsuura, Cathy Schechterly, Krishna Murthy, Francesco M. Marincola, Harvey J. Alter
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This paper is available in a repository.

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Abstract

Recent studies have found hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells (PBMCs) of the majority of presumed recovered subjects. We investigated this unexpected finding using samples from patients whose HCV RNA and anti-HCV status had been serially confirmed. HCV RNA was detected in PBMCs from 66/67 chronic HCV carriers. Subpopulation analysis revealed that the viral load (log copies/106 cells) in B cells (4.14 ± 0.71) was higher than in total PBMCs (3.62 ± 0.71, p