American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(62), 2018
DOI: 10.1128/aac.01462-18
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Neonatal sepsis and its accompanying inflammatory response contribute to substantial morbidity and mortality. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses transcription and production of proinflammatory cytokines, is a candidate adjunctive therapy for newborn sepsis.