Cement-stabilized macadam is commonly used in pavement base courses. The disadvantage of this material is that it easily cracks because construction vehicles cause irreversible fatigue damage to the pavement. Fatigue damage is caused by an insufficient number of maintenance days and overloading by construction vehicles. In order to analyze the influence of the number of maintenance days and overloading by construction vehicles, Miner theory and ABAQUS software were used, and an unconfined compressive strength test, an indirect tensile strength test, a bending tensile strength test, and a fatigue test were carried out simultaneously. The relationship between compressive strength and the splitting strength of water-stabilized macadam as well as compactness, water content, and temperature at different ages were determined. Fitting shows that the bottom tensile stress of the most disadvantageous layer increased with increasing subbase modulus, and its reduction rate increased slowly with the increasing of cement-stabilized macadam subbase thickness. The fatigue prediction equation for cement-stabilized macadam was obtained using bending tensile strength and fatigue tests. Subbase fatigue damage caused by different construction loads under different working conditions was calculated using Miner theory according to actual engineering data. Therefore, the number of pavement maintenance days should be increased. For harsh natural environments and strict time constraints, the design should increase the strength and thickness of the subbase material. When laying the base, overloaded vehicles should be limited, and the construction period of the loaded vehicles should be reduced to minimize road damage.