Aluminum (Al) toxicity in plants is seen in about 15% of the soils worldwide, restraining yields in arable land. In Brazil, acidic soils limit production of wheat (Triticum aestivum L.) and other cereals. Al is toxic for most winter cereals when its concentration increases and soil pH is below 5. One of the main concerns with acidic soil is the increase in the mobility of Al3+ions. Al binds to cell walls in roots, preventing meristematic elongation in sensitive species, causing damage to the root system and results in lower yields. Al3+ forms highly stable complexes with phosphorus (P), limiting its availability to plants, as well as reducing cell division and elongation. To deal with Al toxicity, plants have developed strategies such as organic acid (OA) exudation by roots; this mechanism of detoxification has been well-characterized. OAs, in turn, chelate ions Al3, forming non-toxic compounds that do not penetrate the root system. Some genes responsible for Al tolerance in wheat have been identified, particularly TaALMT1 and TaMATE1B that transport malate and citrate OAs, respectively. In this review, we discussed the mechanisms by which Al damages roots those by which plants are protected, primarily through two genes. We also described the interaction of the ALMT1 gene with P and iron (Fe).