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American Association for the Advancement of Science, Science Signaling, 554(11), 2018

DOI: 10.1126/scisignal.aar6795

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Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

Journal article published in 2018 by Jimin Yuan ORCID, Wan Hwa Ng, Zizi Tian ORCID, Jiajun Yap, Manuela Baccarini ORCID, Zhongzhou Chen ORCID, Jiancheng Hu ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Cancer-associated mutations in the kinase MEK1 increase its dimerization and stimulate RAF-independent signaling.