Salt-Inducible Kinase inhibition suppresses acute myeloid leukemia progression in vivo
Journal article published in 2019 by
Yusuke Tarumoto 
,
Shan Lin ,
Jinhua Wang,
Joseph P. Milazzo,
Yali Xu,
Bin Lu,
Zhaolin Yang ,
Yiliang Wei ,
Sofya Polyanskaya ,
Mark Wunderlich ,
Nathanael S. Gray ,
Kimberly Stegmaier,
Christopher R. Vakoc
,
Shan Lin ,
Jinhua Wang,
Joseph P. Milazzo,
Yali Xu,
Bin Lu,
Zhaolin Yang ,
Yiliang Wei ,
Sofya Polyanskaya ,
Mark Wunderlich ,
Nathanael S. Gray ,
Kimberly Stegmaier,
Christopher R. Vakoc
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Abstract
Transcription factors are important drivers in acute myeloid leukemia (AML), but they are notoriously difficult to target. The authors demonstrate that inhibition of salt-inducible kinase (SIK3) inhibits AML cell proliferation in cells dependent on the transcription factor MEF2C, identifying a small molecule that can disrupt a leukemogenic transcription factor pathway.