Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.

Willeit, Peter; Howson, Joanna M. M.; Kaptoge, Stephen; Young, Robin; Ho, Weang Kee; Wood, Angela M.; Sweeting, Michael; Spackman, Sarah; Staley, James R.; Ramond, Anna; Harshfield, Eric; Nielsen, Sune F.; Grande, Peer; Lange, Leslie A.; Jones, Gregory T.; Scott, Robert A.; Porcu, Eleonora; Thorleifsson, Gudmar; Zeng, Lingyao; Kessler, Thorsten; Nikpay, Majid; Zhang, Weihua; Hopewell, Jemma C.; Kleber, Marcus; Nelson, Christopher P.; Goel, Anuj; Ligthart, Symen; Smith, Albert V.; Qu, Liming; van 't Hof, Femke N. G.; de Bakker, Paul I. W.; van Rij, Andre; Tromp, Gerard; Kuivaniemi, Helena; Ritchie, Marylyn D.; Verma, Shefali S.; Malinowski, Jennifer; de Andrade, Mariza; Kullo, Iftikhar J.; Peissig, Peggy L.; McCarty, Catherine A.; Gottesman, Omri; Muller-Nurasyid, Martina; Rasmussen-Torvik, Laura J.; Pacheco, Jennifer A.; Huang, Jie; Timpson, Nicholas J.; Thompson, Susan D.; Kettunen, Johannes; Mitchell, Gary F.; Parsa, Afshin; Wilkinson, Ian B.; Gorski, Mathias; Li, Yong; Keller, Margaux F.; Langefeld, Carl D.; Weidinger, Stephan; Lubitz, Steven A.; Müller-Nurasyid, M.; Smith, Nicholas L.; Sudman, Marc; Zeggini, Eleftheria; Panoutsopoulou, Kalliope; Thompson, S. D.; Nalls, Mike A.; Singleton, Andrew; Polychronakos, Constantin; Hakonarson, Hakon; Thompson, Deborah; Tomlinson, Ian P.; Hemminki, Kari; Marz, Winfried; Morgan, Gareth; Goldschmidt, Hartmut; Henrion, Marc; Whiffin, Nicola; Wang, Yufei; Iles, Mark M.; Law, Matthew H.; Hayward, Nicholas K.; Luo, Yang; Tybjarg-Hansen, Anne; Nejentsev, Sergey; Sanna, Serena; Soranzo, Nicole; Timothy Bishop, D.; Markus, Hugh S.; Wareham, Nicholas J.; Rader, Daniel J.; Reilly, Muredach; Thompson, Simon G.; Harris, Tamara B.; Houlston, Richard S.; Hofman, Albert; Gudnason, Vilmundur; Tracy, Russell; Psaty, Bruce M.; Watkins, Hugh; Hall, Alistair S.; Samani, Nilesh J.; Maerz, Winfried; Kooner, Jaspal S.; Kathiresan, Sekar; McPherson, Ruth; Majumder, Abdullah Al Shafi; Kastrati, Adnan; Schunkert, Heribert; Stefansson, Kari; März, W.; Walston, Jeremy D.; Thorsteinsdottir, Unnur; Nordestgaard, Borge G.; Netwo, Genomics; Saleheen, Danish; Uk 10k, Consortium; Metastroke, Consortium; Genomic, Aging Res; Spondyloarthri, Australo-Anglo-Amer; Thompson, S. G.; Freitag, Daniel F.; Butterworth, Adam S.; Burgess, Stephen; Bown, Matthew J.; Bevan, Steve; Do, Ron; Delgado, Graciela E.; Bis, Joshua C.; Dehghan, Abbas; Böttinger, E. P.; Crawford, Dana C.; Boettinger, Erwin P.; Crosslin, David R.; Carrell, David S.; Franceschini, Nora; Ganesh, Santhi K.; Bruijn, Lucie; Brown, Matthew A.; Evans, David M.; Ferreira, Manuel A.; Franke, Andre; Felix, Janine F.; Bradfield, Jonathan P.; Easton, Douglas F.; Dunlop, Malcolm; Eisen, Timothy; Chubb, Daniel; Bishop, D. Timothy; Crossman, David; Franco, Oscar H.; Farrall, Martin; Bottinger, Erwin P.; Clarke, Robert; Collins, Rory; Chambers, John C.; Erdmann, Jeanette; Canc, European Prospective Invest; Consortium, Aneurysm; Chowdhury, Rajiv; Di Angelantonio, Emanuele; Consor, Chronic Kidney Dis Genetics; Danesh, John; Consort, Australian Asthma Genetics; Cons, Atrial Fribrillation Genetics; Gene, Consortium Juvenile Arthritis; Ge, Arthritis Res Uk Osteoarthritis; Consortium, Int Parkinson's Dis; Consortium, Breast Canc Assoc; Consortium, Melanoma Genetics; Genetics Consortium, The Interleukin 1.; Con, Myocardial Infarction Genetics; Baas, Annette F.; Ala-Korpela, Mika; Baltic, Svetlana; Allan, James M.; Barbalic, Maja; Assimes, Themistocles; Baurecht, Hansjorg; Alam, Dewan S.; &amp;amp, Elect Med Records; &amp;amp, Cohorts Heart; Al Shafi Majumder, A.; Angelantonio, E. D.

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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.

Journal article published in 2015 by Peter Willeit, Joanna M. M. Howson, Stephen Kaptoge, Robin Young, Weang Kee Ho, Angela M. Wood, Michael Sweeting, Sarah Spackman, James R. Staley, Anna Ramond, Eric Harshfield, Sune F. Nielsen, Peer Grande, Leslie A. Lange, Gregory T. Jones and other authors.

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