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Springer Nature [academic journals on nature.com], Cell Research, 2(22), p. 285-287, 2011

DOI: 10.1038/cr.2011.160

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K-Ras and mitochondria: Dangerous liaisons

Journal article published in 2011 by Jiri Neuzil, Jakub Rohlena ORCID, Lan-Feng Dong ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

It is well documented that the K-RAS oncogene efficiently transforms non-malignant cells, and there is some evidence for the role of mitochondria in this process. Now Peng Huang and colleagues show that K-Ras induction results early on in mitochondria assuming the phenotype consistent with the so-called Warburg effect, i.e., increased glycolysis and attenuated oxidative phosphorylation. Thus the K-Ras protein capable of swift induction of phenotypic changes typical of cancer cells, yet these changes are reversible, and for cells to irreversibly reach their full malignant potential a much longer K-Ras expression is required, implicating mitochondria in the longer-term effects of the oncogene.