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Oxford University Press, Genetics, 3(179), p. 1721-1723, 2008

DOI: 10.1534/genetics.108.090746

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A Key Transcription Cofactor on the Nascent Sex Chromosomes of European Tree Frogs (Hyla arborea)

Journal article published in 2008 by H. Niculita-Hirzel, M. Stöck, N. Perrin ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) within their glutamine-rich central part. These changes have the potential to affect the conformation of the Mediator complex and to activate genes in a sex-specific way and might thus represent the first steps toward the acquisition of a male-specific function. Alternatively, they might result from an ancestral neutral polymorphism, with different alleles picked by chance on the X and Y chromosomes when MED15 was trapped in the nonrecombining segment.