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Wiley, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 8(147B), p. 1392-1398, 2008

DOI: 10.1002/ajmg.b.30878

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Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder

Journal article published in 2008 by Kaixin Zhou, Astrid Dempfle, Mauricio Arcos-Burgos, Steven C. Bakker, Tobias Banaschewski, Joseph Biederman, Jan Buitelaar, Fx Xavier Castellanos, F. Xavier Castellanos, Alysa Doyle, Richard P. Ebstein, Jenny Ekholm, Paola Forabosco, Barbara Franke ORCID, Christine Freitag and other authors.
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Abstract

Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(SR) = 0.00034, P(OR) = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.