Published in
American Association for the Advancement of Science, Science Translational Medicine, 506(11), 2019
DOI: 10.1126/scitranslmed.aav4881
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The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia
Journal article published in 2019 by
Christophe Lechauve 
,
Julia Keith ,
Eugene Khandros ,
Stephanie Fowler,
Kalin Mayberry,
Abdullah Freiwan,
Christopher S. Thom ,
Paola Delbini,
Emilio Boada Romero ,
Jingjing Zhang,
Irene Motta ,
Heather Tillman ,
M. Domenica Cappellini,
Mondira Kundu ,
Mitchell J. Weiss
,
Julia Keith ,
Eugene Khandros ,
Stephanie Fowler,
Kalin Mayberry,
Abdullah Freiwan,
Christopher S. Thom ,
Paola Delbini,
Emilio Boada Romero ,
Jingjing Zhang,
Irene Motta ,
Heather Tillman ,
M. Domenica Cappellini,
Mondira Kundu ,
Mitchell J. Weiss
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Abstract
Rapamycin alleviates β-thalassemia by stimulating ULK1-dependent clearance of toxic free α-globin.