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American Association for the Advancement of Science, Science Advances, 8(5), 2019

DOI: 10.1126/sciadv.aaw1822

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Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

Journal article published in 2019 by Johan M. S. van der Schoot ORCID, Felix L. Fennemann ORCID, Michael Valente, Yusuf Dolen ORCID, Iris M. Hagemans ORCID, Anouk M. D. Becker ORCID, Camille M. Le Gall, Duco van Dalen ORCID, Alper Cevirgel ORCID, Jaco Armando C. van Bruggen, Melanie Engelfriet ORCID, Tomislav Caval ORCID, Arthur E. H. Bentlage ORCID, Marieke F. Fransen ORCID, Maaike Nederend and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We develop a universal platform for CRISPR/HDR-engineering of hybridomas to obtain functionally diverse antibody panels.