Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Uk, Biobank Eye and Vision Consortium; Yamashiro, Kenji; Xie, Jing; van der Spek, Peter J.; van Leeuwen, Elisabeth M.; Zhao, Wanting; van Duijn, Cornelia M.; Zeller, Tanja; Wright, Alan F.; Xu, Liang; Yap, Maurice K. H.; Yazar, Seyhan; Yip, Shea Ping; Zhou, Xiangtian; Yoshimura, Nagahisa; Young, Alvin L.; Zhao, Jing Hua; Wong, Tien Yin; Young, Terri L.; Zheng, Yalin; Woodside, Jayne V.; Yates, Max; Yip, Jennifer L. Y.; Tedja, Milly S.; Hysi, Pirro G.; Furlotte, Nicholas A.; Verhoeven, Virginie J. M.; Consortium, Cream; Iglesias, Adriana I.; Meester-Smoor, Magda A.; Team, 23 and Me Research; Tompson, Stuart W.; Hohn, R.; Khawaja, Anthony P.; Cheng, Ching-Yu; Hoehn, Rene; Wenocur, Adam; Höhn, René; Grazal, Clare; Ms, Tedja; Haller, Toomas; Wojciechowski, Robert; Metspalu, Andres; Wang, Ya Xing; Wedenoja, Juho; Jonas, Jost B.; Mitchell, Paul; Foster, Paul J.; Klein, Barbara E. K.; Klein, Ronald; Paterson, Andrew D.; Hosseini, S. Mohsen; Shah, Rupal L.; Williams, Cathy; Teo, Yik Ying; Tham, Yih Chung; Wilson, James F.; Gupta, Preeti; Pola?ek, O.; Saw, Woei-Yuh; Eriksson, Nicholas; Shi, Yuan; Tai, E.-Shyong; Huffman, Jennifer E.; Sim, Xue Ling; Hayward, Caroline; Bencic, Goran; Rudan, Igor; Polasek, Ozren; Aung, Tin; Veluchamy, Amutha B.; Kähönen, Mika; Burdon, Kathryn P.; Campbell, Harry; Chen, Li Jia; Chen, Peng; Chen, Wei; Chew, Emily; Deangelis, Margaret M.; Pg, Hysi; Ding, Xiaohu; Döring, Angela; Mohsen Hosseini, S.; Mäkelä, Kari-Matti; Feng, Sheng; Fleck, Brian; Fogarty, Rhys D.; Evans, David M.; Fondran, Jeremy R.; Fossarello, Maurizio; Guo, Xiaobo; Haarman, Annet E. G.; He, Mingguang; Janmahasatian, Sarayut; Jhanji, Vishal; Howe, Laura D.; Kaprio, Jaakko; Khaw, Kay-Tee; Willem L. Tideman, J.; Khor, Chiea-Chuen; Krapohl, Eva; Kemp, John P.; Korobelnik, Jean-François; Lee, Kris; Li, Shi-Ming; Lu, Yi; Luben, Robert N.; Shyong Tai, E.; Meguro, Akira; Mihailov, Evelin; McMahon, George; Joshi, Peter K.; Miyake, Masahiro; Mizuki, Nobuhisa; Tsujikawa, Akitaka; Morrison, Margaux; Matsuda, Fumihiko; Nangia, Vinay; Oexle, Konrad; Whisenhunt, Kristina N.; Panda-Jonas, Songhomitra; Pang, Chi Pui; Na, Furlotte; Pirastu, Mario; Plomin, Robert; Rantanen, Taina; Haak, Roxanna; Schache, Maria; Seppälä, Ilkka; Fan, Qiao; Kahonen, M.; Meijers-Heijboer, Hanne; Smith, George D.; Pourcain, B. S.; Cream,; Iyengar, Sudha K.; Tam, Pancy O.; Tideman, J. W. L.; Lass, Jonathan H.; Vaccargiu, Simona; Timpson, Nicholas J.; Vatavuk, Zoran; Hofman, Albert; Wang, Ningli; Rivadeneira, Fernando; Vjm, Verhoeven; Wareham, Nick J.; Uitterlinden, Andre G.; Wang, Jie Jin; Makela, K. M.; Vingerling, Johannes R.; Fah Sathirapongsasuti, J.; Lehtimaki, Terho; Martin, Nicholas G.; Raitakari, Olli T.; Biino, Ginevra; Concas, Maria Pina; Schwantes-An, Tae-Hwi; Ai, Iglesias; Agee, Michelle; Igo, Robert P.; Alipanahi, Babak; Cuellar-Partida, Gabriel; Auton, Adam; Bell, Robert K.; Craig, Jamie E.; Bryc, Katarzyna; Gharahkhani, Puya; Elson, Sarah L.; Williams, Katie M.; Fontanillas, Pierre; Nag, Abhishek; Hinds, David A.; Rahi, Jugnoo S.; McCreight, Jennifer C.; Cumberland, Phillippa M.; Huber, Karen E.; Delcourt, Cecile; Kleinman, Aaron; Bellenguez, Celine; Ma, Meester Smoor; Litterman, Nadia K.; Ried, Janina S.; McIntyre, Matthew H.; Bergen, Arthur A.; Mountain, Joanna L.; Meitinger, Thomas; Noblin, Elizabeth S.; Gieger, Christian; Northover, Carrie A. M.; Pitts, Steven J.; Hewitt, Alex W.; Sathirapongsasuti, J. F.; Mackey, David A.; Sazonova, Olga V.; Simpson, Claire L.; Parssinen, Olavi; Shelton, Janie F.; Pfeiffer, Norbert; St Pourcain, Beate; Shringarpure, Suyash; Tian, Chao; Sw, Tompson; Baird, Paul N.; Vacic, Vladimir; Vitart, Veronique; Wilson, Catherine H.; Amin, Najaf; Aslam, Tariq M.; Bailey-Wilson, Joan E.; Barman, Sarah A.; Barrett, Jenny H.; Saw, Seang-Mei; Blows, Peter; Bishop, Paul N.; Bunce, Catey; Stambolian, Dwight; MacGregor, Stuart; Carare, Roxana O.; Guggenheim, Jeremy A.; Chakravarthy, Usha; Tung, Joyce Y.; Chan, Michelle; Hammond, Christopher J.; Chua, Sharon; Klaver, Caroline C. W.; Crabb, David; Day, Alexander; Desai, Parul; Dhillon, Bal; Egan, Cathy A.; Dick, Andrew D.; Ennis, Sarah; Fruttiger, Marcus; Gallacher, John; Garway Heath, David F.; Gibson, Jane; Gore, Dan M.; Hardcastle, Alison; Harding, Simon P.; Hogg, Ruth E.; Keane, Pearse A.; Khaw, Peng Tee; Lascaratos, Gerassimos; Ap, Khawaja; Lotery, Andrew; Luthert, Phil J.; MacGillivray, Tom J.; Mackie, Sarah L.; Martin, Keith R.; McGaughey, Michelle; McGuinness, Bernadette; McKay, Gareth J.; McKibbin, Martin; Mitry, Danny; Moore, Tony; Morgan, James E.; Muthy, Zaynah A.; O'Sullivan, Eoin; Owen, Chris; Patel, Praveen J.; Paterson, Euan N.; Peto, Tunde; Petzold, Axel; Rudnicka, Alicja R.; Self, Jay E.; Cy, Cheng; Sivaprasad, Sobha; Van Der Spek, P. J.; Steel, David H. W.; Stratton, Irene M.; Strouthidis, Nicholas; Van Leeuwen, E. M.; Sudlow, Cathie L. M.; Thaung, Caroline; Thomas, Dhanes; Trucco, Emanuele; Tufail, Adnan; Vernon, Stephen A.; Viswanathan, Ananth C.; Pärssinen, Olavi; Van Duijn, C. M.; Ao, David Mackey; Team, 23andMe Res; Ccw, Klaver; Uk, Biobank Eye Vis Consortium

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Seyhan Yazar
Uk et al., 2018

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Nature Research, Nature Genetics, 6(50), p. 834-848, 2018

DOI: 10.1038/s41588-018-0127-7

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@article{Uk2018,
  author = {Uk, Biobank Eye and Vision Consortium and Yamashiro, Kenji and Xie, Jing and van der Spek, Peter J. and van Leeuwen, Elisabeth M. and Zhao, Wanting and van Duijn, Cornelia M. and Zeller, Tanja and Wright, Alan F. and Xu, Liang and Yap, Maurice K. H. and Yazar, Seyhan and Yip, Shea Ping and Zhou, Xiangtian and Yoshimura, Nagahisa and Young, Alvin L. and Zhao, Jing Hua and Wong, Tien Yin and Young, Terri L. and Zheng, Yalin and Woodside, Jayne V. and Yates, Max and Yip, Jennifer L. Y. and Tedja, Milly S. and Hysi, Pirro G. and Furlotte, Nicholas A. and Verhoeven, Virginie J. M. and Consortium, Cream and Iglesias, Adriana I. and Meester-Smoor, Magda A. and Team, 23 and Me Research and Tompson, Stuart W. and Hohn, R. and Khawaja, Anthony P. and Cheng, Ching-Yu and Hoehn, Rene and Wenocur, Adam and Höhn, René and Grazal, Clare and Ms, Tedja and Haller, Toomas and Wojciechowski, Robert and Metspalu, Andres and Wang, Ya Xing and Wedenoja, Juho and Jonas, Jost B. and Mitchell, Paul and Foster, Paul J. and Klein, Barbara E. K. and Klein, Ronald and Paterson, Andrew D. and Hosseini, S. Mohsen and Shah, Rupal L. and Williams, Cathy and Teo, Yik Ying and Tham, Yih Chung and Wilson, James F. and Gupta, Preeti and Pola?ek, O. and Saw, Woei-Yuh and Eriksson, Nicholas and Shi, Yuan and Tai, E.-Shyong and Huffman, Jennifer E. and Sim, Xue Ling and Hayward, Caroline and Bencic, Goran and Rudan, Igor and Polasek, Ozren and Aung, Tin and Veluchamy, Amutha B. and Kähönen, Mika and Burdon, Kathryn P. and Campbell, Harry and Chen, Li Jia and Chen, Peng and Chen, Wei and Chew, Emily and Deangelis, Margaret M. and Pg, Hysi and Ding, Xiaohu and Döring, Angela and Mohsen Hosseini, S. and Mäkelä, Kari-Matti and Feng, Sheng and Fleck, Brian and Fogarty, Rhys D. and Evans, David M. and Fondran, Jeremy R. and Fossarello, Maurizio and Guo, Xiaobo and Haarman, Annet E. G. and He, Mingguang and Janmahasatian, Sarayut and Jhanji, Vishal and Howe, Laura D. and Kaprio, Jaakko and Khaw, Kay-Tee and Willem L. Tideman, J. and Khor, Chiea-Chuen and Krapohl, Eva and Kemp, John P. and Korobelnik, Jean-François and Lee, Kris and Li, Shi-Ming and Lu, Yi and Luben, Robert N. and Shyong Tai, E. and Meguro, Akira and Mihailov, Evelin and McMahon, George and Joshi, Peter K. and Miyake, Masahiro and Mizuki, Nobuhisa and Tsujikawa, Akitaka and Morrison, Margaux and Matsuda, Fumihiko and Nangia, Vinay and Oexle, Konrad and Whisenhunt, Kristina N. and Panda-Jonas, Songhomitra and Pang, Chi Pui and Na, Furlotte and Pirastu, Mario and Plomin, Robert and Rantanen, Taina and Haak, Roxanna and Schache, Maria and Seppälä, Ilkka and Fan, Qiao and Kahonen, M. and Meijers-Heijboer, Hanne and Smith, George D. and Pourcain, B. S. and Cream,  and Iyengar, Sudha K. and Tam, Pancy O. and Tideman, J. W. L. and Lass, Jonathan H. and Vaccargiu, Simona and Timpson, Nicholas J. and Vatavuk, Zoran and Hofman, Albert and Wang, Ningli and Rivadeneira, Fernando and Vjm, Verhoeven and Wareham, Nick J. and Uitterlinden, Andre G. and Wang, Jie Jin and Makela, K. M. and Vingerling, Johannes R. and Fah Sathirapongsasuti, J. and Lehtimaki, Terho and Martin, Nicholas G. and Raitakari, Olli T. and Biino, Ginevra and Concas, Maria Pina and Schwantes-An, Tae-Hwi and Ai, Iglesias and Agee, Michelle and Igo, Robert P. and Alipanahi, Babak and Cuellar-Partida, Gabriel and Auton, Adam and Bell, Robert K. and Craig, Jamie E. and Bryc, Katarzyna and Gharahkhani, Puya and Elson, Sarah L. and Williams, Katie M. and Fontanillas, Pierre and Nag, Abhishek and Hinds, David A. and Rahi, Jugnoo S. and McCreight, Jennifer C. and Cumberland, Phillippa M. and Huber, Karen E. and Delcourt, Cecile and Kleinman, Aaron and Bellenguez, Celine and Ma, Meester Smoor and Litterman, Nadia K. and Ried, Janina S. and McIntyre, Matthew H. and Bergen, Arthur A. and Mountain, Joanna L. and Meitinger, Thomas and Noblin, Elizabeth S. and Gieger, Christian and Northover, Carrie A. M. and Pitts, Steven J. and Hewitt, Alex W. and Sathirapongsasuti, J. F. and Mackey, David A. and Sazonova, Olga V. and Simpson, Claire L. and Parssinen, Olavi and Shelton, Janie F. and Pfeiffer, Norbert and St Pourcain, Beate and Shringarpure, Suyash and Tian, Chao and Sw, Tompson and Baird, Paul N. and Vacic, Vladimir and Vitart, Veronique and Wilson, Catherine H. and Amin, Najaf and Aslam, Tariq M. and Bailey-Wilson, Joan E. and Barman, Sarah A. and Barrett, Jenny H. and Saw, Seang-Mei and Blows, Peter and Bishop, Paul N. and Bunce, Catey and Stambolian, Dwight and MacGregor, Stuart and Carare, Roxana O. and Guggenheim, Jeremy A. and Chakravarthy, Usha and Tung, Joyce Y. and Chan, Michelle and Hammond, Christopher J. and Chua, Sharon and Klaver, Caroline C. W. and Crabb, David and Day, Alexander and Desai, Parul and Dhillon, Bal and Egan, Cathy A. and Dick, Andrew D. and Ennis, Sarah and Fruttiger, Marcus and Gallacher, John and Garway Heath, David F. and Gibson, Jane and Gore, Dan M. and Hardcastle, Alison and Harding, Simon P. and Hogg, Ruth E. and Keane, Pearse A. and Khaw, Peng Tee and Lascaratos, Gerassimos and Ap, Khawaja and Lotery, Andrew and Luthert, Phil J. and MacGillivray, Tom J. and Mackie, Sarah L. and Martin, Keith R. and McGaughey, Michelle and McGuinness, Bernadette and McKay, Gareth J. and McKibbin, Martin and Mitry, Danny and Moore, Tony and Morgan, James E. and Muthy, Zaynah A. and O'Sullivan, Eoin and Owen, Chris and Patel, Praveen J. and Paterson, Euan N. and Peto, Tunde and Petzold, Axel and Rudnicka, Alicja R. and Self, Jay E. and Cy, Cheng and Sivaprasad, Sobha and Van Der Spek, P. J. and Steel, David H. W. and Stratton, Irene M. and Strouthidis, Nicholas and Van Leeuwen, E. M. and Sudlow, Cathie L. M. and Thaung, Caroline and Thomas, Dhanes and Trucco, Emanuele and Tufail, Adnan and Vernon, Stephen A. and Viswanathan, Ananth C. and Pärssinen, Olavi and Van Duijn, C. M. and Ao, David Mackey and Team, 23andMe Res and Ccw, Klaver and Uk, Biobank Eye Vis Consortium},
  doi = {10.1038/s41588-018-0127-7},
  journal = {Nature Genetics},
  month = {jan},
  pages = {834-848},
  title = {Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error},
  url = {http://www.nature.com/articles/s41588-018-0127-7.pdf},
  volume = {50},
  year = {2018}
}

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