Published in
American Society for Microbiology, Journal of Virology, 3(93), 2019
DOI: 10.1128/jvi.01823-18
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Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells
Journal article published in 2018 by
Sai Priya Anand,
Jérémie Prévost,
Sophie Baril,
Jonathan Richard,
Halima Medjahed,
Jean-Philippe Chapleau,
William D. Tolbert,
Sharon Kirk,
Amos B. Smith,
Bruce D. Wines,
Stephen J. Kent 
,
P. Mark Hogarth ,
Matthew S. Parsons,
Marzena Pazgier ,
Andrés Finzi
,
P. Mark Hogarth ,
Matthew S. Parsons,
Marzena Pazgier ,
Andrés Finzi
This paper is made freely available by the publisher.
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Abstract
The “open” CD4-bound conformation of HIV-1 envelope glycoproteins is the primary target of antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies present in HIV-positive (HIV + ) sera, such as anti-coreceptor binding site and anti-cluster A antibodies. Here we report that the binding of these two families of antibodies is required to engage FcγRIIIa and mediate ADCC.