Significance Neurodegenerative disorders touch many lives in the form of various diseases. Therapeutic interventions of such disorders are limited due to the difficulty in reaching the neurons by crossing the impermeable blood–brain barrier. Scientists have created nanoscopic particles to take therapeutics to the brain; however, the results have not been very encouraging due to the inefficient ability of the nanoplatforms in crossing the blood–brain barrier and to accumulate in the target neuron cells effectively as uptake of nanomaterials by neurons is difficult to achieve. We provide a biodegradable nanoparticle platform with efficient brain astrocyte accumulation properties to provide an alternative approach to tackle neurodegenerative processes by improving and enhancing astrocyte’s natural protection ability toward neurons for neuromedicine.