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American Society for Microbiology, Clinical and Vaccine Immunology, 6(21), p. 904-907, 2014

DOI: 10.1128/cvi.00147-14

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Avidity of Antibodies against Infecting Pneumococcal Serotypes Increases with Age and Severity of Disease

Journal article published in 2014 by Amelieke J. H. Cremers ORCID, Jonneke Lut, Peter W. M. Hermans, Jacques F. G. M. Meis, Marien I. de Jonge, M. I. de Jonge, Gerben Ferwerda
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The incidence of invasive pneumococcal disease (IPD) rises with age. Among adult IPD patients, the avidity of antipneumococcal polysaccharide antibodies against the infecting serotype increased with age and severity of disease, indicating that susceptibility to IPD in the elderly may rather be due to flaws in other aspects of opsonophagocytosis.