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Elsevier, Cell, 6(157), p. 1253-1254, 2014

DOI: 10.1016/j.cell.2014.05.022

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Getting a Grip on piRNA Cluster Transcription

Journal article published in 2014 by Alexandra Sapetschnig, Eric A. Miska ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

The generation of piRNAs from long primary transcripts requires specialized factors that distinguish these precursors from canonical RNA polymerase II transcripts. Mohn et al. and Zhang et al. provide evidence that in Drosophila melanogaster noncanonical transcription coupled with splicing inhibition differentiates piRNA precursors from mRNAs and ensures their correct processing.