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Elsevier, NeuroImage: Clinical, (4), p. 641-648, 2014

DOI: 10.1016/j.nicl.2014.02.004

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Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis

Journal article published in 2014 by Rd D. Newbould, R. Nicholas, Cl L. Thomas, R. Quest, Js S. Z. Lee, L. Honeyfield, A. Colasanti, O. Malik, M. Mattoscio, Pm M. Matthews ORCID, M. P. Sormani ORCID, Ad D. Waldman, Pa A. Muraro
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

•Magnetization transfer MRI was used in a cohort of 40 MS subjects differing by age.•MTR metrics were different between MS groups and controls, as expected.•MTR in normal appearing tissue did not differ between age-stratified MS groups.•MTR in white matter lesions was strongly different between age-stratified MS groups.•Results imply an age-related effect in tissue integrity in MR-visible lesions.