Elsevier, NeuroImage: Clinical, (4), p. 649-658, 2014
DOI: 10.1016/j.nicl.2014.04.005
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•We examine MRI white matter T2-weighted hyperintense lesions, “UBOs” in NF1.•Myelin water and intra- and extracellular water fractions are unchanged in UBOs.•Diffusivity is higher, while mean kurtosis and neurite density are lower in UBOs.•The combined measures suggest that UBOs may arise from intramyelinic edema.•Combining diffusion MRI and multi-exponential T2 relaxation has added value.