Published in
Elsevier, NeuroImage: Clinical, (4), p. 649-658, 2014
DOI: 10.1016/j.nicl.2014.04.005
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Characterizing the microstructural basis of “unidentified bright objects” in neurofibromatosis type 1: A combined in vivo multicomponent T2 relaxation and multi-shell diffusion MRI analysis
Journal article published in 2014 by
Thibo Billiet,
Burkhard Mädler,
Felice D'Arco,
Felice D’Arco,
Ronald Peeters,
Sabine Deprez 
,
Ellen Plasschaert,
Alexander Leemans ,
Hui Zhang,
Bea Van den Bergh,
Bea Van den Bergh,
Mathieu Vandenbulcke,
Eric Legius,
Stefan Sunaert,
Louise Emsell
,
Ellen Plasschaert,
Alexander Leemans ,
Hui Zhang,
Bea Van den Bergh,
Bea Van den Bergh,
Mathieu Vandenbulcke,
Eric Legius,
Stefan Sunaert,
Louise Emsell
This paper is made freely available by the publisher.
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Abstract
•We examine MRI white matter T2-weighted hyperintense lesions, “UBOs” in NF1.•Myelin water and intra- and extracellular water fractions are unchanged in UBOs.•Diffusivity is higher, while mean kurtosis and neurite density are lower in UBOs.•The combined measures suggest that UBOs may arise from intramyelinic edema.•Combining diffusion MRI and multi-exponential T2 relaxation has added value.