Published in
American Society for Microbiology, Infection and Immunity, 1(75), p. 504-507, 2007
DOI: 10.1128/iai.00058-06
Links
- ORCID
- American Society for Microbiology | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [eprints.kingston.ac.uk] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages
Journal article published in 2007 by
Vania Rosas-Magallanes,
Gustavo Stadthagen-Gomez,
Jean Rauzier,
Luis B. Barreiro,
Ludovic Tailleux,
Frédéric Boudou,
Ruth Griffin 
,
Jérome Nigou,
Mary Jackson,
Brigitte Gicquel,
Olivier Neyrolles
,
Jérome Nigou,
Mary Jackson,
Brigitte Gicquel,
Olivier Neyrolles
This paper is made freely available by the publisher.
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Abstract
ABSTRACT Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.