Dissemin is shutting down on January 1st, 2025

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BioMed Central, BMC Microbiology, 1(10), p. 175

DOI: 10.1186/1471-2180-10-175

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A distinctive 'microbial signature' in celiac pediatric patients

Journal article published in 2010 by Serena Schippa, Valerio Iebba, Maria Barbato, Giovanni Di Nardo, Valentina Totino, Monica Proietti Checchi, Catia Longhi, Giulia Maiella, Salvatore Cucchiara ORCID, Maria Pia Conte
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Celiac Disease (CD) is an autoimmune disorder of the small intestine in which dietary gluten ingestion leads to a chronic enteropathy. Recently, scientific evidence suggested a potential role of gut microbiota in CD. To have a snapshot of dominant duodenal microbiota we analyzed the mucosa-associated microbiota of 20 children with CD, before and after a gluten-free diet (GFD) regimen, and of 10 controls. Total DNA was extracted from duodenal biopsies and amplification products of 16S ribosomal DNA were compared by temporal temperature gradient gel electrophoresis (TTGE). TTGE profiles were analyzed by statistical multivariate analysis. Results: The average number of bands in TTGE profiles was significantly higher (P