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Public Library of Science, PLoS ONE, 5(7), p. e34364, 2012

DOI: 10.1371/journal.pone.0034364

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IL1RL1 Gene Variants and Nasopharyngeal IL1RL-a Levels Are Associated with Severe RSV Bronchiolitis: A Multicenter Cohort Study

Journal article published in 2012 by Tina E. Faber, Annemieke Schuurhof, Annelies Vonk, Gerard H. Koppelman ORCID, Marije P. Hennus, Jan L. L. Kimpen, Riny Janssen, Louis J. Bont
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Targets for intervention are required for respiratory syncytial virus (RSV) bronchiolitis, a common disease during infancy for which no effective treatment exists. Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma. Human IL1RL1 encodes three isoforms, including soluble IL1RL1-a, that can influence IL33 signalling by modifying inflammatory responses to epithelial damage. We hypothesized that IL1RL1 gene variants and soluble IL1RL1-a are associated with severe RSV bronchiolitis.