In the title compound, C18H16Cl2O4, the dihedral angle between the benzene rings is 82.40 (4)°. The meth­oxy groups at both meta positions of the 3,4,5-trimeth­oxy­phenyl ring are slightly twisted from the aromatic ring [C—O—C—C = −166.60 (8) and −6.18 (13)°], whereas the meth­oxy group at the para position is almost perpendicular [C—O—C—C = 112.08 (9)°]. The ketone O atom is connected to the 2,4-dichloro­phenyl group through a Car—Car—C—O (ar = aromatic) torsion angle of −116.43 (9)°. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds into infinite chains along the b axis. The crystal structure also features C—H⋯π inter­actions.