Published in
American Society for Cell Biology, Molecular Biology of the Cell, 11(23), p. 2156-2169
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Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner
Journal article published in 2012 by
Eloy Bejarano,
Henrique Girao 
,
Andrea Yuste,
Bindi Patel,
Carla Marques,
David C. Spray,
Paulo Pereira,
Ana Maria Cuervo
,
Andrea Yuste,
Bindi Patel,
Carla Marques,
David C. Spray,
Paulo Pereira,
Ana Maria Cuervo
This paper is made freely available by the publisher.
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Abstract
Connexins modulate intercellular communication when assembled in gap junctions. Compromised macroautophagy increases cellular communication due to failure to degrade connexins at gap junctions. Nedd4-mediated ubiquitinylation of the connexin molecule is required to trigger its autophagy-dependent internalization and degradation.