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Multiscale modeling of fluid transport in tumors.

Journal article published in 2008 by Sj Jonathan Chapman ORCID, S. Jonathan Chapman, Rj Shipley ORCID, Rossa Jawad
This paper is available in a repository.
This paper is available in a repository.

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Preprint: policy unknown
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Postprint: policy unknown
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Abstract

A model for fluid flow through the leaky neovasculature and porous interstitium of a solid tumor is developed. A network of isolated capillaries is analyzed in the limit of small capillary radius, and analytical expressions for the hydraulic conductivities and fractional leakage coefficients derived. This model is then homogenized to give a continuum description in terms of the vascular density. The resulting equations comprise a double porous medium with coupled Darcy flow through the interstitium and vasculature.