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National Academy of Sciences, Proceedings of the National Academy of Sciences, 23(101), p. 8670-8675, 2004

DOI: 10.1073/pnas.0402644101

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Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

Journal article published in 2004 by Gabrielle T. Belz ORCID, Christopher M. Smith, Lauren Kleinert, Patrick Reading, Andrew Brooks, Ken Shortman, Francis R. Carbone, William R. Heath ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8α – CD11b – DC subset and distinct CD8α + lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.