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BMJ Publishing Group, Journal of Clinical Pathology, 12(58), p. 1255-1260

DOI: 10.1136/jcp.2005.026161

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mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic disease

Journal article published in 2005 by R. Gibbs, A. Davies, S. Soumian, C. Albrecht ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Atherosclerotic plaque behaviour is influenced by intraplaque inflammation, matrix turnover, and the lipid core volume. Peroxisome proliferator activated receptor γ (PPARγ) modulates atherosclerosis by its anti-inflammatory and anti-protease activity. PPARγ promotes lipid efflux through the liver X receptor α (LXRα) and the ATP binding cassette transporter A1 (ABCA1). Matrix metalloproteinase 9 (MMP-9) and cyclooxygenase 2 (COX-2) are implicated in plaque instability.