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Oxford University Press (OUP), Bioinformatics, 20(27), p. 2888-2894

DOI: 10.1093/bioinformatics/btr496

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Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty

Journal article published in 2011 by Anthony R. Soltis ORCID, Jeffrey J. Saucerman ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: Biological networks are robust to a wide variety of internal and external perturbations, yet fragile or sensitive to a small minority of perturbations. Due to this rare sensitivity of networks to certain perturbations, it is unclear how precisely biochemical parameters must be experimentally measured in order to accurately predict network function.